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Detection of HER2 through Antibody Immobilization Is Influenced by the Properties of the Magnetite Nanoparticle Coating
dc.contributor.author | Villegas-Serralta, Enrique | |
dc.date.accessioned | 2018-12-05T20:44:24Z | |
dc.date.available | 2018-12-05T20:44:24Z | |
dc.date.issued | 2018-04-02 | |
dc.identifier.uri | http://cathi.uacj.mx/20.500.11961/4568 | |
dc.description.abstract | Considerable effort has been focused on improving the control of size, shape, and surface modifications to detect proteins. The purpose of this study was to compare the efficiencies of aminosilane-coated magnetite (As-M) nanoparticles (NPs), dextran-coated magnetite nanoparticles (Dx-M), and bare nanoparticles for conjugating single-chain variable fragment antibodies (scFvs) with the aim of detecting the human epidermal growth factor receptor 2 (HER2) protein. Dx-M and As-M NPs were characterized using scanning electron microscopy, energy dispersive X-ray spectroscopy, X-ray diffraction, and Raman spectroscopy. Dx-M and As-M were conjugated with a monoclonal scFv for active targeting of the HER2 antigen. Aminosilane surface coating enhanced the scFv conjugation efficiency over twofold compared to that of the dextran-coated magnetite NPs for the detection of HER2 proteins. | es_MX |
dc.description.uri | https://www.hindawi.com/journals/jnm/2018/7571613/ | es_MX |
dc.language.iso | en_US | es_MX |
dc.relation.ispartof | Producto de investigación IIT | es_MX |
dc.relation.ispartof | Instituto de Ingeniería y Tecnología | es_MX |
dc.rights | Atribución 2.5 México | * |
dc.rights.uri | http://creativecommons.org/licenses/by/2.5/mx/ | * |
dc.subject | HER2 | es_MX |
dc.subject | nanomedicine | es_MX |
dc.subject | biomedical engineering | es_MX |
dc.subject | nanoparticles | es_MX |
dc.subject | antibody immobilization | es_MX |
dc.subject.other | info:eu-repo/classification/cti/2 | es_MX |
dc.subject.other | info:eu-repo/classification/cti/7 | es_MX |
dc.title | Detection of HER2 through Antibody Immobilization Is Influenced by the Properties of the Magnetite Nanoparticle Coating | es_MX |
dc.type | Artículo | es_MX |
dcterms.thumbnail | http://ri.uacj.mx/vufind/thumbnails/rupiiit.png | es_MX |
dcrupi.instituto | Instituto de Ingeniería y Tecnología | es_MX |
dcrupi.cosechable | Si | es_MX |
dcrupi.norevista | 2018 | es_MX |
dc.identifier.doi | doi.org/10.1155/2018/7571613 | es_MX |
dc.contributor.coauthor | Zavala, Oscar | |
dc.contributor.coauthor | Chapa, Christian | |
dc.contributor.coauthor | Garcia Casillas, Perla E | |
dc.journal.title | Journal of Nanomaterials | es_MX |
dc.lgac | Sin línea de generación | es_MX |
dc.cuerpoacademico | Sin cuerpo académico | es_MX |
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