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pH-responsive polymer micelles for methotrexate delivery at tumor microenvironments
dc.contributor.author | Castro Carmona, Javier Servando | |
dc.date.accessioned | 2020-12-23T17:56:11Z | |
dc.date.available | 2020-12-23T17:56:11Z | |
dc.date.issued | 2020-11-16 | es_MX |
dc.identifier.uri | http://cathi.uacj.mx/20.500.11961/15894 | |
dc.description.abstract | Methotrexate (MTX) anticancer drug was successfully loaded and released in a controlled manner from polymer micelles made of a diblock copolymer of poly(monomethoxy ethylene glycol)-b-poly(ε-caprolactone) (mPEG-PCL). The empty and MTX-loaded micelles (MTX/mPEG-PCL) were characterized by electron microscopy. The drug release dependence upon pH 5.4, 6.5, and 7.4 for 30 days was proven and characterized by UV-Vis spectroscopy. The cytotoxic effect of MTX/ mPEG-PCL micelles on MCF-7 breast cancer cells was evaluated through an MTT assay. The morphological analysis indicated the successful formation of micelles of 76 and 131 nm for empty and MTX-loaded micelles, respectively. An encapsulation efficiency of 70.2% and a loading capacity of 8.8% were obtained. The in vitro release of MTX showed a gradual and sustained profile over 22 days, with a clear trend to much higher release at acidic pH (80 and 90% for pH 6.7 and 5.5, respectively). The MTX/mPEG-PCL micelles showed an IC50 of MCF-7 cells at 30 µg mL−1 . The results suggested that MTX/mPEG-PCL could be a promising drug delivery system for cancer treatment | es_MX |
dc.description.uri | https://doi.org/10.1515/epoly-2020-0064 | es_MX |
dc.language.iso | en | es_MX |
dc.relation.ispartof | Producto de investigación IIT | es_MX |
dc.relation.ispartof | Instituto de Ingeniería y Tecnología | es_MX |
dc.subject | cancer treatment, copolymer micelles, drug delivery system, encapsulation efficiency, methotrexate | es_MX |
dc.subject.other | info:eu-repo/classification/cti/7 | es_MX |
dc.title | pH-responsive polymer micelles for methotrexate delivery at tumor microenvironments | es_MX |
dc.type | Artículo | es_MX |
dcterms.thumbnail | http://ri.uacj.mx/vufind/thumbnails/rupiiit.png | es_MX |
dcrupi.instituto | Instituto de Ingeniería y Tecnología | es_MX |
dcrupi.cosechable | Si | es_MX |
dcrupi.norevista | 1 | es_MX |
dcrupi.volumen | 20 | es_MX |
dcrupi.nopagina | 624-635 | es_MX |
dc.identifier.doi | https://doi.org/10.1515/epoly-2020-0064 | es_MX |
dc.journal.title | E-Polymers | es_MX |
dc.lgac | BIOMATERIALES Y SISTEMAS DE LIBERACIÓN DE FÁRMACOS | es_MX |
dc.cuerpoacademico | Ciencia e Ingeniería de Materiales | es_MX |
dc.contributor.authorexterno | Carrillo Castillo, Teresa Darlen | |
dc.contributor.coauthorexterno | Luna Velasco, Antonia | |
dc.contributor.coauthorexterno | Zaragoza Contreras, Armando Erasmo |