Biointegration study of a pva-hec scafffold for the regeneration of adipose tissue of mastectomized women

Abstract

Tissue engineering provides numerous biomaterials as structural materials to improve or replace biological functions, in this case improving quality of life of cancer patients of breast. Today, reconstructive surgery offers only fat rotation and use of silicone/saline implants to solve the problem. In this way, we obtained a scaffold based in a hydrogel of PVA-HEC that exhibit all these characteristics. The scaffold developed was adequate to promote the regeneration of adipose tissue in a thoracic area of female BalbC mice with excellent results. Histological images showed stable fat formation since the first month without adverse reaction or necrosis. By other hand, these images showed the total adsorption of the scaffold in four months without evidence of rejection of the implant. These results proved the capability of this scaffold to promote the formation of new adipose tissue and the formation of new blood vessel in the tissue.