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dc.date.accessioned2024-12-02T18:48:56Z
dc.date.available2024-12-02T18:48:56Z
dc.date.issued2024-06-29es_MX
dc.identifier.urihttps://cathi.uacj.mx/20.500.11961/29228
dc.description.abstractRed wines and their pomace are valuable sources of phenolic compounds (PCs), which have been proposed as potential contributors to their cardioprotective effect through the inhibition of platelet aggregation. The antiplatelet activity of an extract depends on its chemical composition, specifically the presence of certain phenolic compounds, as well as the interactions between them affecting biological activity. In order to assess the effect on platelet aggregation, we investigated the effect of the grape pomace PC enrichment of a Merlot wine, as well as the effect of the five major phenolic compounds present in wine extracts: caffeic acid, gallic acid, quercetin, epicatechin, and catechin. We analyzed how their combination influenced platelet aggregation. We found that the fortified wine sample with the highest PC content (W8) exhibited a potent antiplatelet effect in aggregation and platelet activation assays induced by the agonists TRAP-6, collagen, and ADP, with its activity being most potent against the les_MX
dc.language.isoenes_MX
dc.relation.ispartofProducto de investigación ICBes_MX
dc.relation.ispartofInstituto de Ciencias Biomédicases_MX
dc.rightsCC0 1.0 Universal*
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.subjectwine extractses_MX
dc.subjectplatelet aggregationes_MX
dc.subjectphenolic compundses_MX
dc.subject.otherinfo:eu-repo/classification/cti/6es_MX
dc.titleAntiplatelet Activity of Phenolic Compounds-Fortified Merlot Wine and Pure Phenolic Compoundses_MX
dc.typeArtículoes_MX
dcterms.thumbnailhttp://ri.uacj.mx/vufind/thumbnails/rupiicb.pnges_MX
dcrupi.institutoInstituto de Ciencias Biomédicases_MX
dcrupi.cosechableSies_MX
dcrupi.norevista14es_MX
dcrupi.volumen13es_MX
dc.identifier.doihttps://doi.org/10.3390/app14135707es_MX
dc.contributor.coauthorAlvarez-Parrilla, Emilio
dc.contributor.coauthorMuñoz-Bernal, Oscar A.
dc.journal.titleApplied Scienceses_MX
dc.contributor.authorexternoRodriguez, Lyanne
dc.contributor.coauthorexternoFuentes, Eduardo
dc.contributor.coauthorexternoPalomo, Iván
dcrupi.pronacesNingunoes_MX


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