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Identification of factors associated with increased CRABP1 gene expression in patients with squamous intraepithelial lesions and cervical cancer
dc.contributor.author | Arellano Ortiz, Ana Lidia | |
dc.date.accessioned | 2023-12-27T19:42:57Z | |
dc.date.available | 2023-12-27T19:42:57Z | |
dc.date.issued | 2023-09-14 | es_MX |
dc.identifier.uri | http://cathi.uacj.mx/20.500.11961/26580 | |
dc.description.abstract | Cellular Retinoic Acid Binding Protein-1 (CRABP1) facilitates retinoid metabolism; however, an abnormal expression might influence cancers developed. Biopsy samples were evaluated from patients with cervical cancer (CC), high-grade (HSIL), and low grade squamous intraepithelial lesions (LSIL) (n= 66) Clinic/pathological information was obtained from patients. CRABP1 gene expression was examined by RT-PCR and CRABP1 protein by immunohistochemistry (IHC) techniques. The expression of the CRABP1 gene is shown to be significantly lower in the HSIL group (p= 0.008). CRABP1 protein was expressed in 90.3% of tissues, and only in CC was presented absence of protein (9.7%). Overweight/obesity might increase the gene (p= 0.019) but not the protein expression (p= 0.053). Also, a gene expression increase was shown in high serum retinol concentration (p= 0.047) and the presence of HVP-16 (p= 0.011) (gene expression but not the protein, p > 0.05). Menopause patients were associated with an absent/weak CRABP1 immunostaining (p= 0.008). Finally, CRABP1 and associated factors might be used as biomarkers to track the progression and persistence of cervical cancer on tissue | es_MX |
dc.description.uri | http://tip.zaragoza.unam.mx/index.php/tip/article/view/586 | es_MX |
dc.language.iso | en | es_MX |
dc.relation.ispartof | Producto de investigación ICB | es_MX |
dc.relation.ispartof | Instituto de Ciencias Biomédicas | es_MX |
dc.rights | Atribución-NoComercial-SinDerivadas 2.5 México | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/2.5/mx/ | * |
dc.subject | cáncer de cuello uterino | es_MX |
dc.subject | CRABP1 | es_MX |
dc.subject | obesidad | es_MX |
dc.subject | retinol | es_MX |
dc.subject | lesiones intraepiteliales escamosas | es_MX |
dc.subject.other | info:eu-repo/classification/cti/3 | es_MX |
dc.title | Identification of factors associated with increased CRABP1 gene expression in patients with squamous intraepithelial lesions and cervical cancer | es_MX |
dc.title.alternative | Identificación de factores asociados al aumento de la expresión génica de CRABP1 en pacientes con lesiones intraepiteliales escamosas y cáncer de cuello uterino | es_MX |
dc.type | Artículo | es_MX |
dcterms.thumbnail | http://ri.uacj.mx/vufind/thumbnails/rupiicb.png | es_MX |
dcrupi.instituto | Instituto de Ciencias Biomédicas | es_MX |
dcrupi.cosechable | Si | es_MX |
dcrupi.norevista | 26 | es_MX |
dcrupi.nopagina | 1-13 | es_MX |
dc.identifier.doi | https://doi.org/10.22201/fesz.23958723e.2023.586 | es_MX |
dc.contributor.coauthor | Jimenez Vega, Florinda | |
dc.journal.title | TIP - Revista Especializada en Ciencias Químico-Biológicas | es_MX |
dc.contributor.coauthorexterno | Salcedo-Vargas, Mauricio | |
dc.contributor.coauthorexterno | Muñiz-Hernández, Saé | |
dc.contributor.alumnoprincipal | 8294 | es_MX |
dcrupi.pronaces | Salud | es_MX |
dcrupi.vinculadoproyint | Fondo sectorial de investigación y seguridad social SSA/IMSS/ISSSTE-CONACYT, SALUD-2014-01-233271 | es_MX |