Mango “Ataulfo” peel extract improves metabolic dysregulation in prediabetic Wistar rats

Abstract

The hypoglycemic effect of functional phytochemicals has been evaluated in diabetic rodents but scarcely in its premorbid condition (prediabetes; PD). This study aimed to evaluate a mango (cv. Ataulfo) peel hydroethanolic (20:80) extract (MPE) for in vivo glycemic/lipidemic-normalizing effect and in vitro enzyme inhibitory ( -amylase/ -glucosidase) activity. The polyphenolic MPE (138 mg EAG.g����1, mainly gallic acid and mangiferin) with antioxidant capacity (DPPH 34 mgTE g����1) was fed to PD rats (induction: high-fat diet (60% energy) + single dose streptozotocin (35 mg kg����1), 4 weeks). At the 8th week, fasting glycemia (FG), oral glucose tolerance test, and insulin sensitivity indexes (HOMA-IR, HOMA- ) > blood lipid-normalizing effect were documented as healthy controls > MPE > disease (PD) controls, which was possibly related to the extract’s concentration–response in vitro enzyme inhibitory activity (IC50 0.085 mg mL����1). MPE is a rich source of glucose-lowering phytochemicals for the primary prevention of type 2 diabetes.